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Alexan (Spironolactone)
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Spironolactone

Alexan is a synthetic 17-Alexan corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Alexan competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for active clinical trials using this agent.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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Alexan comes as a tablet and suspension (liquid; Carospir) to take by mouth. It usually is taken once or twice a day. Take Alexan suspension consistently either with food or without food each time. Take Alexan at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Alexan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the oral suspension well before each use to mix the medication evenly.

Your doctor may start you on a low dose of Alexan and gradually increase your dose.

Alexan tablets and suspension release the medication differently in your body and cannot be substituted for one another. Only take the Alexan product prescribed by your doctor and do not switch to a different Alexan product unless your doctor says that you should.

Alexan controls high blood pressure, edema, heart failure, and hyperaldosteronism but does not cure these conditions. It may take about 2 weeks or longer before the full effect of Alexan occurs. Continue to take Alexan even if you feel well. Do not stop taking Alexan without talking to your doctor.

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Measurement of liver iron content by magnetic resonance imaging in 20 patients with overt porphyria cutanea tarda before phlebotomy therapy: a prospective study. Applying the transient error reconstruction algorithm in the assessment of the cerebral blood flow. Histopathology showed a malignant neoplasm with increased vascularity, indicating the possibility of a primary uterine cervical melanoma. Expression of the proliferating cell nuclear antigen 2 (atPCNA 2), MutS 3 homolog (atMSH 3) and MutL1 homolog (atMLH1) genes in shoots of Arabidopsis was strongly induced by exposure to 0.75 mg L(-1) Cd, but were repressed by other Cd concentrations whereas exposure to 0.75-6 mg L(-1) of Cd resulted in a decreased expression of atPCNA1, atMSH 2, 6 and 7 genes independently of any observable biological effects, including survival, fresh weight and chlorophyll level of shoots.

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Intraoperative frozen section analysis of sentinel lymph nodes in breast cancer patients: a meta-analysis and single-institution experience. Three independent indications were found for p-type conducting, phosphorus-doped ZnO nanorods: first, acceptor-related CL peaks, second, opposite transfer characteristics of back-gate field effect transistors using undoped and phosphorus doped wire channels, and finally, rectifying I-V characteristics of ZnO:P nanowire/ZnO:Ga p-n junctions. Thumb deformities are common manifestations of rheumatoid arthritis and represent a significant source of disability.

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Longitudinal evaluation of the occurrence of MRI-detectable bone marrow edema in osteoarthritis of the knee. To demonstrate this approach, we consider models of liquid aluminum and sodium. Among various endogenous factors examined, increased production of NGF was demonstrated in the cells treated with neurotrophin-3 (NT-3) for 24 h. Rather the question now is how to treat this elderly group of patients.

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Globaltest and GOEAST: two different approaches for Gene Ontology analysis. Euglycemic male Wistar rats were pithed under anesthesia and arterial blood pressure was measured. We speculate that the phage AsiA orthologs, Rsd, and AlgQ are members of a related family in T4-type phage and bacteria, which interact similarly with primary sigma factors. Therefore the use of a CGM system, as a means of assessing the measures of glycemic variability, could improve the management of insulin therapy in these patients. Transcriptome analysis of cyaA (encoding adenylate cyclase) and crp (encoding cAMP receptor protein) deletion mutants revealed that cAMP-CRP negatively regulates transcription of both VPS biosynthesis genes and genes encoding biofilm matrix proteins.

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Among chronic SCI patients, 22 patients with upper motor neuron bowel (UMNB) and 20 patients with lower motor neuron bowel (LMNB) participated in an interview survey for the evaluation of bowel care patterns. The experimental results compare well with the theoretical predictions. Interestingly, some biochemical data are inconsistent with a known high-resolution crystal structure of the catalytic intermediate of the protein, and biophysical data indicate that the protein undergoes conformational changes that affect enzyme activity. These engineering techniques are still works in progress, requiring optimization to improve the therapeutic efficacy and targeting effectiveness while minimizing any loss of MSC function. Prochloraz-induced oocyte maturation in rainbow trout (Oncorhynchus mykiss), a molecular and functional analysis.

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Dry hot air: is it a reliable method of disinfection for urological endoscopes? Indeed, analysis of bigenic mouse models indicates that two genetic events are generally required for progression from HGPIN to locally invasive adenocarcinoma and that two to five genetic events can promote metastasis to distant sites.

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Amino acid-decarboxylase activity of bacteria isolated from fermented pork sausages. The classical cortico-reticular theory on absence epilepsy suggests that a hyperexcitable cortex is a precondition for the occurrence of absence seizures. There is a compound which is very similar to ferulic acid in the decoction of Herb Leonuri. We suggest that the downregulation of MRP by beta3 is not required for increased cell spreading but instead that MRP downregulation is a secondary effect of increased cell spreading. Combined DFT and NBO study on the electronic basis of Si...N-beta-donor bond.

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We aimed to elucidate the pretreatment platelet count in prediction of extrahepatic metastasis of HCC during the follow-up. The effect of O-chlorobenzylidene malononitrile (CS) on the immune system was studied in mice given 8 and 16 mg/kg body weight i.p. Eighty-one patients received 6 mega units of natural interferon-alpha intramuscularly daily for 2 weeks and then 3 times a week for 22 weeks. The results suggest that I3C may exert anticandidal activity by binding to DNA.

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Our results shed light on the cell biology of SLITRK1, including its protein phosphorylation and potential molecular pathways for SLITRK1 function, and should contribute to further understanding the role of SLIRTK1 in developmental neuropsychiatric conditions such TS, OCD, and ADHD. A mutation in the X chromosome at the ZIC3 gene was found in two affected siblings (one male, one female) and their unaffected mother. Seed rain dynamics following disturbance exclusion in a secondary tropical dry forest in Morelos, Mexico.

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This study also indicates that SDC-1 and -4 may be required for HepG2, Hep3B and Huh7 human hepatoma cell migration, invasion or spreading induced by the chemokine. A 6-year-old castrated male Shih Tzu was evaluated because of intermittent bleeding during urination.

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Extensive brain lesions involved white matter in three, and basal ganglia and corpus callosum in one each. The modified G-H-K equation is used to calculate the resting membrane potential in neurons. There is a rapid decline in serum hCG within the first few days after early medication abortion.

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: All patients admitted from 2000 through 2005 who had early-onset bloodstream infection, defined as presence of both a positive blood culture drawn within 1 day before or within 48 hrs after hospital admission and an appropriate diagnostic code for infection. HLA-A and HLA-B antigens in acute leukemia: A2--B12 phenotypes correlate with longer survival in acute myelogenous leukemia. Body weights, mortality and rectal temperatures were lower and food conversion higher for stock G3 than G1 or G2. This has created a cadre of terms that are often used interchangeably but have different meanings among various disciplines. In individuals following an LCKD or an LFD, blood pH decreased mildly and the LCKD group experienced a small, transient decrease in serum bicarbonate in conjunction with mild ketosis.

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Physical exercise interventions are safe in the subacute and rehabilitative phases of recovery for humans with ABI. Results of EFAs indicated strong support for two-factor structure, with social communication and stereotyped behavior factors. Dielectric properties of thermo-reversible hydrogels: the case of a dextran copolymer grafted with poly(N-isopropylacrylamide).

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(18)F-labeled tyrosine derivatives: synthesis and experimental studies on accumulation in tumors and abscesses Free and bound phenolic compounds in barley (Hordeum vulgare L.) flours. To evaluate maternal outcomes of a support intervention for families of children with selected chronic illnesses. Cadherin-11 is expressed in detrusor smooth muscle cells and myofibroblasts of normal human bladder.

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In another group, tear access was denied-in vivo, by bathing the cornea continuously in saline or by keeping the lids open, or ex vivo, by rinsing the denuded cornea before incubating the enucleated eyeball. The optimal concentration of glucose was 30 g/L for sophorolipid production.

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On immunoelectrophoresis u-TPI1 migrated in the alpha 2-region and u-TPI2 in the beta 1-region. Adding HCV treatment to HIV treatment in HIV-HCV coinfected patients: the impact on the different dimensions of fatigue and self-reported side effects. Suction, salvage, sutures, and potions: blood management post-aprotinin.

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Planning for the optimal design of studies to personalize antipsychotic prescriptions in the post-CATIE era: the clinical and pharmacoepidemiological data suggest that pursuing the pharmacogenetics of metabolic syndrome complications (hypertension, diabetes mellitus and hyperlipidemia) may be a reasonable strategy. In addition, a magnetic resonance imaging scan of the injured knee was offered to all patients. The purpose of this study was to examine inequalities of access to health care among the urban elderly in northwestern China. Small, dense LDL are associated with a 3 fold increase in the risk of ischemic heart disease, but does not remain a significant risk factor after adjustment for triglyceride levels. cis-Dicarbonyl-cis-dichlorido-trans-bis(triphenylphosphine-kappaP)iridium(III) tetrafluoridoborate, formed by reaction of (cycloocta-1,5-diene)bis(triphenylphosphine)iridium tetrafluoridoborate with carbonyl fluoride in dichloromethane solution.

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Medicolegal consequences of postoperative intra-abdominal adhesions. To report a patient with lattice corneal dystrophy type I (LCDI) who developed a triple anterior chamber after full-thickness lamellar keratoplasty (LKP). The results shown are important because the hnRNP K protein might represent a new target for pharmacologic intervention in virus replication and cancer. (2) Does migration among compartments limit the effectiveness of refugia?

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However, the conical coupling that connects the various modules has several shortcomings. To investigate whether changes in neuronal excitability occur in the subiculum after KA-SE, we examined the age-dependent effects of SE on the bursting neurons of subiculum, the major output region of the hippocampus.

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Comparison of Broselow tape measurements versus physician estimations of pediatric weights. The relationship between body size and the urinary excretion of the main histamine metabolite tele-methylimidazoleacetic acid in man.

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Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines. Because there was no visual feedback, corrective saccades could only be driven by an internally generated error signal.

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Oral administration of sildenafil to a 35-year-old white male patient suffering from incapacitating PSS with severe pulmonary arterial hypertension and acral ulcers induced a clinically significant reduction in dyspnea and increase in walking distance within one week as well as complete and long-lasting healing of all ulcers within five weeks. PKD3 may contribute to the malignant progression of prostate cancer cells through negative regulation of MMP-7 expression. Expression of neutral endopeptidase (NEP/CD10) on pancreatic tumor cell lines, pancreatitis and pancreatic tumor tissues. Urban pools in green spaces have the potential to act to its dwellers like corridors through the urban matrix.

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Three hundred seven patients had SCC (OTR: 153, control: 154), and 246 patients had BCC (OTR: 123, control: 123). Perceived discrimination and health outcomes a gender comparison among Asian-Americans nationwide. We used genome-wide ancient DNA analyses to investigate the genetic origins of three enslaved Africans whose remains were recovered on the Caribbean island of Saint Martin. Further, patients surviving their hydrocephalus exhibited no worse functional deterioration if they required surgical intervention.

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HVEM may play a critical role in tumor progression and immune evasion, and may also be a novel prognostic marker and potential therapeutic target in human CRC. Older panel members rated boys significantly more attractive than younger panel members. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Experiments using 2,2-dimethylGA(4), a GA(4) analog resistant to gibberellin 2-oxidase, in combination with ga2ox2 mutant seeds suggest that the efficiency of deactivation of exogenous GA(4) by AtGA2ox2 is dependent on light conditions, which partly explains phytochrome-mediated changes in gibberellin effectiveness (sensitivity) found in previous studies. Experience with bacillus Calmette-Guerin in patients with superficial bladder carcinoma.

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This may result from uneven distribution of bone density in the femoral cervix. Hypothalamic neuropeptide gene expression during recovery from food restriction superimposed on short-day photoperiod-induced weight loss in the Siberian hamster. These observations suggest important differences in the mechanism of action between ketamine and MK-801. A pre- and postintervention study was initiated with 732 men undergoing robot-assisted radical PCa surgery over a 3-yr period, 396 men before the introduction of the QAP and 336 afterwards. Early/initiating oncogenic mutations have been identified for many cancers, but such mutations remain unidentified in uveal melanoma (UM).

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Local perceptions of the forms, timing and causes of behavior change in response to the AIDS epidemic in Zimbabwe. Only a few cases involving the tricuspid and pulmonary valves have been reported. However, little is known about the sex-specific differences of ER expression in colorectal cancer (CRC). Subjects pointed caudally to the target locations and made the largest errors, which were on the order of centimeters, when performing in the horizontal posture. The leading edge of 3 T 3 cells showed a similar organization but with fewer radiating thin filament bundles.

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Using data-driven model-brain mappings to constrain formal models of cognition. This study provides further support for the competition-colonization tradeoff and successional niche theory as opposed to models of neutrality and ecological equivalence. The true incidence of CDH is still difficult to estimate because of the high incidence of hidden mortality of CDH. Growth of tetrahedral silver nanocrystals in aqueous solution and their SERS enhancement.

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The secondary cell lines may succumb to shear forces under these conditions. This study demonstrates the high prevalence of falls and fall-related injuries in stroke survivors, and identifies factors that increase the risk. These sensors include a DC accelerometer and RF magnetic sensor. Two failure modes were observed: rupture or tearing of the pit membrane by the microprobe tip, and the stretching of the pit membrane until the torus was forced out of the pit chamber through the pit aperture without rupture, a condition we refer to as torus prolapse.

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Test plates were automatically read and results were recorded using the BIOMIC image analysis plate reader system (Giles Scientific, USA). Nitrogen sorption data confirm that the magnetite-loaded silica particles possess typical mesopore structure with BET surface area of about 183 m(2)/g. We studied 44 elderly men with diabetic nephropathy who participated in a clinical trial.

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A total of 75 peptides, corresponding to 53 proteins, were quantified with oxidative modification. To evaluate the outcomes of viscotrabeculotomy in patients with primary congenital glaucoma and to compare the success and complications rates with classical trabeculotomy. The presented study evaluated the outcome of endovascular procedure in cases of thoracic aortic pathology according to the implanted thoracic stent graft devices.

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Inadvertent ureteric ligation: diagnosis using multidetector computed tomography. Influence of carbohydrate-protein beverage on cycling endurance and indices of muscle disruption. We describe a case of irreversible subacute sclerotic combined degeneration of the spinal cord in a Western vegan subject. The econutrition application to postoperative patients with colorectal diseases is beneficial in alleviating gastrointestinal symptom and diarrhea, and correcting intestine flora disturbance.

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Single-cell and two-dimensional computerized numerical modeling of the sinoatrial node was conducted to validate the theoretical predictions using established ionic kinetics of the rabbit pacemaker and atrial cells. We undertook a prospective cohort study of 568 community-dwelling patients with RA by using observational data from clinically detailed telephone interviews at baseline and 2 years later in addition to medical record abstraction.

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These include single particle trapping with micron-scale accuracy at arbitrary positions over waveguide lengths of several millimeters, definition of multiple independent particle traps in a single waveguide, and combination of optical trapping with single particle fluorescence analysis. Endothelin-converting enzyme-1 (ECE-1), the key enzyme responsible for endothelin-1 generation, has been linked to coronary artery disease (CAD). Awareness and utilization of emergency medical services by limited English proficient caregivers of pediatric patients. In addition, it must form a dimer to function as a histidine kinase like all the other histidine kinases.

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CFTR (-) cells had lower extracellular levels of both GSH and SCN and were more sensitive to HOCl-mediated injury. We report two cases of transient MRI lesions of the splenium of the corpus callosum related to hypoglycemia. Such treatment also increased the susceptibility of hexamers and high molecular weight (HMW) isoforms to dissociation by SDS. The most noteworthy technical advance of CVH Project was the construction of a low temperature laboratory, which contributed to the prevention of small structures (including teeth, concha nasalis, and articular cartilage) from falling off out of the milling surface. Seeds from a transgenic line of Arabidopsis which overexpressed a CAO-GFP fusion were mutagenized and their progenies were screened by laser-scanning confocal microscopy for mutants showing an elevated level of GFP fluorescence.

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The results show that rosiglitazone had superior efficacy to placebo for inducing clinical response and remission. Heterologous protein secretion by bacillus species from the cradle to the grave. A perspective on testing of existing pharmaceutical excipients for genotoxic impurities.

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Arthroscopic single- versus double-bundle posterior cruciate ligament reconstructions using hamstring autograft. Complications and patient satisfaction after transobturator anterior and/or posterior tension-free vaginal polypropylene mesh for pelvic organ prolapse. The divergent C-terminal hypervariable region was postulated to contain Rab targeting information.

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Synostosis between pubic bones due to neurogenic, heterotopic ossification. Proteasomal degradation appears responsible for the decrease of both Mdm2 and p21(CIP1/WAF1), as MG-132 prevented their degradation and revealed AF-induced Mdm2 polyubiquitylation. In a series of Drosophila mutants with changes in the brain structure, some characters (reduced life span, behavioral changes, and neuronal loss in various brain regions) resemble symptoms observed in human patients with neurodegenerative diseases. Clinical levofloxacin tablet usp monograph for fish oils and experimental studies have associated Blastocystis with intestinal inflammation, and it has been shown that Blastocystis has potential to modulate the host immune response. Food irradiation: a public health challenge for the 21st century.

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Ascaris nidagel alcohol interaction haemoglobin as an indicator of the oxygen produced by isolated chloroplasts. Does the information content of an irrelevant source differentially affect spoken word recognition in younger and older adults?

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Patients who may benefit from the administration of drotrecogin alfa (activated) are currently those at high risk of death, and other indications should be better defined by ongoing trials. Different species of Laupala sing distinctively and show species-specific acoustic preferences. Internal medicine department chairs: where they come from, why they leave, where they go. A procedure for including activity against enveloped viruses in harnalidge d tablet zip the post-contamination treatment of hands has been recommended, but so far no European standard is available to implement it.

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Furthermore, stimuli associated with more responding under increasing schedule requirements generally were more effective in treating destructive behavior than stimuli associated with less responding. These changes were accompanied with a significant reduction in muscle fibre diameter. Kinetic and thermodynamic studies revealed that the Michael-aldol reaction is reversible under conditions in which lexapro vs eldepryl benefits trimethylsilyl iodide is used in the presence of hexamethyldisilazane at ambient temperature. Do children and adolescents have differential response rates in placebo-controlled trials of fluoxetine? Correlation with in vitro itraconazole susceptibility distinguished the following three profiles: susceptible, resistant, and showing a paradoxical effect.