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Cryofaxol (Cyclophosphamide)
+ BONUS
 
Cyclophosphamide

Cryofaxol is a potent immunosuppressant that can decrease the immune response by blocking the production of DNA in cells. Cryofaxol is used for severe complications of lupus, systemic sclerosis (scleroderma), some forms of vasculitis, myopathies, such as polymyositis and dermatomyositis; and sometimes rheumatoid arthritis.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Cryofaxol is used alone or in combination with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that first appear as skin rashes); multiple myeloma (a type of cancer of the bone marrow); and certain types of leukemia (cancer of the white blood cells), including chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute myeloid leukemia (AML, ANLL), and acute lymphoblastic leukemia (ALL). It is also used to treat retinoblastoma (cancer in the eye), neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children), ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), and breast cancer. Cryofaxol is also used to treat nephrotic syndrome (a disease that is caused by damage to the kidneys) in children whose disease has not improved, has gotten worse, or has come back after taking other medications or in children who experienced intolerable side effects with other medications. Cryofaxol is in a class of medications called alkylating agents. When Cryofaxol is used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. When Cryofaxol is used to treat nephrotic syndrome, it works by suppressing your body's immune system.

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Evaluation of three antimicrobial regimens used as metaphylaxis in stocker calves at high risk of developing bovine respiratory disease. They suggest that AcrB captures ligands primarily from the periplasm. The study consisted of 472 children, who received routine dental treatment.

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The mechanism of how betaine does this is postulated to be that betaine causes the increase in the elimination rate by increasing the metabolic rate which generates NAD the rate limiting cofactor of alcohol oxidation by ADH. A mechanism for the observed degradation based on mechanically generated radicals from microcrystalline cellulose is proposed.

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Conduct and attentional problems in childhood and adolescence and later substance use, abuse and dependence: results of a 25-year longitudinal study. Clinical studies were successfully performed on 25 patients, and the results were of high quality and were reproducible. The findings of the current study suggest that successful recovery of motor skill after hemiparetic stroke involves participation of the contralesional cortical network. Human Demodex mites (Demodex folliculorum and Demodex brevis) are unique in that they are an obligate human ectoparasite that can inhabit the pilosebaceous unit lifelong without causing obvious host immune response in most cases.

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Recombinant human granulocyte colony-stimulating factor administration in a case of neutropenia due to increased neutrophil sequestration. The authors describe a modified technique for extraction of a dislocated crystalline lens or large and hard lens fragments displaced into the vitreous cavity. Trajectory generation for robotic needle insertion in soft tissue. The anterolateral thigh adipofascial flap is advantageous in that it can provide a reliable vascular pedicle with relatively thin, pliable soft tissue and direct primary closure of the donor site.

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A Course of Lectures on Surgery: Delivered in the Medical School of Cambridge. Microsatellite instability (MSI) is the hallmark of a molecular pathway to carcinogenesis due to sporadic or inherited abnormalities of DNA mismatch repair genes. Total bacterial count in raw milk from the dairy farms that characterize the zone northwest of Santa Fe and south of Santiago del Estero

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These monolayer and multilayer DNA/amphiphilic polycation complex Langmuir-Blodgett films were used as templates and nanoreactors for generation of inorganic nanostructures via metal cation binding with DNA and following inorganic phase growth reactions. Specifically, using signed weighted gene co-expression network analysis (WGCNA), we found a pluripotency module and a differentiation module, which are not identified in unsigned networks. Gastroesophageal reflux is a frequent, varied disease, which spoils the quality of life.

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However, not all infected cells induced arrest or deceleration of pathogen-specific T cells, and dense clusters of infected cells were poorly accessible to migrating T cells. Development of emergency medicine programs in Israel and Canada: a tale of two countries. These findings suggest that exercise may help to reduce anxiety by altering 5-HT systems, perhaps by down-regulating postsynaptic 5HT 2B/2C receptors. Superficial venous pathology in the Asian population of South West London--a prospective study.

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Allergy to coconut is infrequent, with only 5 cases reported so far in the medical literature. c-Myc interacts with the pre-replicative complex and localizes to early sites of DNA synthesis. In August 2007, a group of specialized researchers and healthcare professionals met to discuss the state of Chagas infection diagnosis and to build a consensus for a plan of action to develop efficient, affordable, accessible and easy-to-use diagnostic tests for Chagas disease. Local anesthesia and routine oral analgesic did not significantly reduce postoperative pain after mini-laparoscopic surgeries in children and young adults.

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Our findings suggest that skin T-lymphocytes from atopic dermatitis patients seem to consist of a heterogenous population of Th1 and Th2 or Th0 cells and the results for secreted cytokines indicate that T-cell lines from each inflammatory skin disease showed the corresponding disease-specific original cytokine profile. Detachmentwas assessed as the difference between net removal (particle counts) and deposition (FM counts). However, historically it has been plagued by limited durability and marked acetabular bone loss. TLE-MTS showed extensive, widespread but predominantly ipsilateral temporal and also extratemporal T(2) relaxation rate decreases.

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An anonymous postal piloted questionnaire was sent to all 66 general surgery specialist trainees in one UK training region between January and March 2005. NIRCA is suitable for screening relatively long sequences (up to 1kb) while SSCP is less sophisticated, robust and allows for mutant bands to be extracted from polyacrylamide gel when required.

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To test the hypothesis that the presence of preeclampsia, small for gestational age (SGA)-birth, and placental abruption in the first pregnancy confers increased risk in the second pregnancy. The levels of ACTH-R and cytochrome P450 side chain cleavage enzyme (P450scc) mRNAs were determined by Northern blot analysis. The serine/threonine kinase glycogen synthase kinase-3beta (GSK-3beta) is expressed in two, alternatively spliced, isoforms: a short form (GSK-3beta1) and a long form containing a 13 amino acid insert in the catalytic domain (GSK-3beta2). A strategy for staged coagulation with intermediate ozonation was proposed for waters containing both humic and non-humic NOM for maximum DOC and specific UV absorbance at 254nm (SUVA) removal. During late embryonic development the thoracic neuromeres of the crayfish contain arrays of mitotically active neuroblasts similar to those previously described in the spider crab and lobster.

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Some of the small ubiquitin-linked peptides that are a hallmark of Doa4 deficiency are not present in rsp5 mutant cells or after overproduction of a variant ubiquitin modified at Lys 63 (UbK63R). Intrinsic-signal optical imaging confirms that direct electrical stimulation elicits robust, dynamic changes in cerebral blood flow, which must accompany NO and CO signaling. The remaining patients require lifelong monitoring in primary care and careful attention to their cardiovascular risk factors.

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Physiological function of arginine and its metabolites in plants Analysis of antireflection-structured surfaces with continuous one-dimensional surface profiles. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage. A phase I study was performed in patients with advanced solid tumors to determine the maximum tolerated dose (MTD), establish a safety profile, and to evaluate pharmacokinetics and efficacy of the drug. The disease is transmitted by the bite of an infected, female, phlebotomine sand fly, causing skin lesions that can appear weeks to years after a bite.

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Centralisation of cancer surgery has occurred with prostate cancer (PCa) surgery only being commissioned at a single designated pelvic cancer surgical centre. Adult neurogenesis is an exciting and rapidly advancing field of research.

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None of the serotonin receptor (5-HT(1A), 5-HT(1B), or 5-HT(2C)) disruptions in mice have resulted in cardiovascular defects. Academic branding: erythema ab igne and use of laptop computers. RNase treatment of the thymus extract increased the recovery in Sm of the same bands compared to untreated extract. A favorable outcome of acute myeloid leukemia (AML) has recently been described in these patients whereas the prognosis of acute lymphoblastic leukemias (ALL) is similar to that in other children. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.

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Secreted phospholipases A(2) (sPLA(2)s) represent a new class of human immunodeficiency virus (HIV) inhibitors that block the early steps of virus entry into cells. The inhibitory effect of antimycin is greatly enhanced under aerobic conditions and is due to its effect as an uncoupler of photophosphorylation. Anti-VEGF therapy for age-related macular degeneration was named as one of the top ten science advancements of the year 2006. The possibility of a shorter treatment protocol requiring lower amounts of gonadotrophins should be considered in view of its economic advantage. House dust, occurrence and biology of the house dust mite, the house dust allergen

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Multimodal evaluation of CSF dynamics following extradural decompression for Chiari malformation Type I. Self-injurious behavior is the most outstanding feature of Lesch-Nyhan syndrome and has recently been ascribed to an obsessive-compulsive behavior. Activity in both areas was also high when drawing the displayed cartoons. This review describes some of the physiological effects of recombinant human erythropoietin (EPO) in healthy humans.

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These PDE findings were consistent with the shunt flows in angiocardiography. WHO working on a severity scale to accompany pandemic alert phases. Biocomputational analysis was carried out to identify structural differences between the P. We propose to investigate the mechanisms leading to epileptic seizures by using a self-organising map (SOM) based similarity index (SI) measure. On examination, a round, soft, nonpulsatile submucosal mass in the cartilagenous vault of the right nasal cavity was found.

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We conducted a retrospective study (1984-2011) in which a description of the clinical and epidemiological characteristics of MRSA arthritis in adults was performed and then compared to native joint infections caused by MRSA vs. pylori eradication when used together with amoxycillin (750 mg three times a day) and metronidazole (500 mg three times a day) for a 7-day treatment period. To determine whether docosahexaenoic acid can protect against hereditary retinal degenerations in transgenic mice expressing the V20G, P23H, and P27L (VPP) rhodopsin mutations.

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The concentrations of IL-1beta and TNF-alpha in tear fluid washings and in corneal and conjunctival epithelia were measured by ELISA. The results are generally similar to those of Western countries.

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The reactions of these chlorofluorocarbons (CFCs) substitutes have been studied under pseudo-first-order kinetic conditions in excess of the fluorinated compounds over Cl atoms. Therefore, this study was undertaken to investigate the effect of crude extracts, alkaloidal fraction, and isolated substance derived from Indigofera truxillensis in photodynamic antimicrobial chemotherapy on the viability of bacteria and yeast and evaluation of mechanisms involved.

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Influence of melatonin pretreatment and preconditioning by hypobaric hypoxia on the development of cortical photothrombotic ischemic lesion. Although more studies seem to favour the two-stage BVT approach, evidence in the literature is not sufficient to draw a final conclusion as the difference between the one-stage and the two-stage approaches for creation of a BB-AVF is not statistically significant in terms of the overall maturation rate and postoperative complications. Some children with reduced functional bladder capacity also have nocturnal polyuria.

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All three anesthetics caused dose-dependent decreases in cardiovascular function. aeruginosa revealed the highest affinity for the bisphenol of the three organisms tested, it was most resistant to its antibacterial action. The organism was isolated from synovial fluid in 7/11 cases and from urethral and vaginal secretions in 9/20 cases. Classification, description, and illustration of gender-specific chest imaging findings are the objective of this article.

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However, there is no considerable evidence that the possible oestrogenic production of this tumor may be the cause of endometrial disorders. One, the largest, includes healthy patients and the other includes those with medical conditions that necessitate further evaluation. A significant decrease in blood pressure was found in the group consuming mineral water at 2 and 4 weeks.

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The study reveals the physical origin of the chessboard structure. Renin and Nt-proANP, measured with individuals on their habitual diet, could be useful biomarkers to identify individuals with the greatest blood pressure-lowering benefit from reduced salt intake. There are no reports of protocols using segmental ischemia in porcine models. We have developed a numerical model for calculating the electromagnetic scattering from thick microholographic gratings using the Born approximation and the direct volume integral.

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Clinical pharmacist counseling improves outcomes for Taiwanese asthma patients. Parasite replication and the evolutionary epidemiology of parasite virulence. Pentachlorophenol (PCP) is globally dispersed and contamination of soil with this biocide adversely affects its functional biodiversity, particularly of fungi - key colonizers.

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Detection of actin-binding proteins in human platelets by 125I-actin overlay of polyacrylamide gels. In this study, patients who underwent cryoballoon ablation required a lower dose of morphine compared with those who underwent radiofrequency ablation. Our large-scale study of American specimens characterized the relationship between pedicle dimensions and a variety of demographic factors such as age, sex, body height and weight. In addition, subclinical bacterial biofilms have been identified from some cases of seemingly aseptic implant loosening. A review of pediatric HIV effects on neurocognitive development.

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The distal end was soft and covered by haired skin, whereas the proximal end was firm, covered with mucosal epithelium, and at the point of transection contained a fully developed tooth. Differences in aluminum equivalent values of endodontic sealers: conventional versus digital radiography. In its acute and chronic forms, the disease is likely to remain prevalent in the developing world until issues of ignorance, poverty and prompt access to appropriate and efficacious medical care are addressed. Comprehensive Meta-analysis 2.0 software (CMA 2.0) was used for statistical analysis of the data retrieved from selected case-cohort studies. Directed three-dimensional patterning of self-assembled peptide fibrils.

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cationic) and in the hydrocarbon chain lengths (main and spacer chains). The study was based on interviews and criminality data involving 32 users of AAS who had sought treatment for AAS-related problems at a psychiatric addiction clinic in Sweden. Are smokers receptive to using smokeless tobacco as a substitute?

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Supershift experiments identified specific binding of the transcription factors Elf-1 and Elk-1 to the -844G allele. Patients in ROCKET AF were recruited from 45 countries and had AF and risk factors putting them at moderate-to-high risk of stroke, with or without heart failure.

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Implant sites healed submerged for 10 weeks, at which time sacrifice took place and sections were prepared, processed, and analyzed histomorphometrically. To avert the combinational explosion, in this paper, we use Estimation of Distribution Algorithms (EDAs) to search the space. We explain how to build influence diagrams (IDs) that explicitly represent cost and effectiveness.

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It has been observed that disruptions in skin patterns are larger for malignant melanoma (MM) than benign lesions. The number of activated externally vertices is a small fraction of the entire network. The measurements of ionic conductivity and diffusion coefficients obtained for the neat BMIBr (molten phase) and for the BMIBr-SO2 strongly suggest a higher degree of ionic association in the presence of SO2. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.

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This shift, being detectable only before an adapted saccade, disappears at some time around saccade onset. This offers the possibility of introducing branched substituents at C-5 of the furan ring. Taken together, these data indicate that the Ton box of FhuA may always be available for interactions with TonB, implying that transporter-TonB interactions in FhuA are either constitutive or not regulated by the Ton box configuration.

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Efficacy of Adderall and methylphenidate in attention deficit hyperactivity disorder: a reanalysis using drug-placebo and drug-drug response curve methodology. The typical patient is an elderly, hypertensive female with sigmoid deformity of the intraventricular septum. A model of Miss Poland finalists figure assessment is presented which allows one to distinguish super-attractive women from the control group.

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We used the predominant immunoassay platforms for prolactin to assay serum samples treated with polyethylene glycol (PEG) and establish and validate reference intervals for total and monomeric prolactin. An interaction between the helicase domain of the Tobacco mosaic virus (TMV) 126-/183-kDa replicase protein(s) and the Arabidopsis thaliana NAC domain transcription factor ATAF2 was identified via yeast two-hybrid and in planta immunoprecipitation assays. Familial dysbetalipoproteinemia (FD), also known as type III hyperlipoproteinemia, is a genetic dyslipidemia characterized by elevated very low density lipoprotein (VLDL) and chylomicron remnant particles that confers increased risk of cardiovascular disease (CVD). Primary end points were time to first recurrence and time to progression.

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Purification and protective efficacy of monomeric and modified Yersinia pestis capsular F1-V antigen fusion proteins for vaccination against plague. Alternatively, other sildenafil side effects headache on left factors could be responsible for the exaggerated PRL responses to TRH noted in these patients with primary ovarian failure.

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Molecular control of blood flow and angiogenesis: role of nitric oxide. Separation and determination of clenbuterol by HPLC using a vancomycin chiral stationary phase. injections of the vasodilator agents were given just distal to the flow probe. Results belmazol 20 mg posologie metronidazole suggest that patients presenting to eating-disorder services in different countries have clinical features that fall into very similar patterns. Early confirmation of human exposure to any serotype of BoNT is an important public health goal.

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The relationship between the hemorrhagic blood dyscrasias and hypermenorrhea. To compare matched populations of LASIK and Visian Implantable Collamer Lens (ICL) cases in the correction of myopia between -3.00 and -7.88 diopters (D). Comparative analysis of rat survival under effect of acute heating and of poisons of animals belonging to different taxonomic groups However, no published studies have examined the latent structure of negative response bias on cognitive tests: measures of cognitive symptom exaggeration may evaluate a continuum of gordius 300 mg gabapentin per day poor effort/invalid responding or a dichotomy of adequate versus inadequate effort.

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To estimate predictors of direct costs and costs of hospitalization related to cardiovascular disease (CVD) in patients with atrial fibrillation (AF) recruited to the Euro Heart Survey on AF (EHS-AF) in Greece, Italy, Poland, Spain, and the Netherlands. Y6-1 by organic solvent (methanol:chloroform:1-butanol) after vacuum freeze drying and the extracted biosurfactant was purified by silica gel column chromatography. Restriction atovarol 20 mg fragment size analyses were performed by visualizing digested polymerase chain reaction products for ACE and PAI-1 genotypes.

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Family history for alcoholism had a direct association with two aspects of drinking. The proposed way forward hepaid forte mod de administrare augmentin for South African medical teams responding to disasters is to be unified under a leading academic body, to have an up-to-date volunteer database, and for volunteers to be current with the international search and rescue course currently being developed by the Medical Working Group of INSARAG. Maize was harvested 135 days after (63)Ni input and radioactivity determined in both vegetal and water samples. Our approach relies on selective molecular recognition of one enantiomer of the target molecule using a DNA aptamer, and the ability of aptamer-based biosensors to transduce the presence of a target molecule into a dose-dependent fluorescence signal.

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The effectiveness of thymectomy on seronegative generalized myasthenia gravis: comparing with seropositive cases. Approaches to automatic calibration of HSPF using the nonlinear parameter estimator PEST (Parameter Estimation Tool) with its Gauss-Marquardt-Levenberg (GML) method, Random multiple Search Method (RSM), and Shuffled Complex Evolution method developed at the University of Arizona (SCE-UA) are presented. dutasteride soft gelatin capsules dissolution Referring each individual CgA result to the proposed reference range (or cut-off value) we must take into account whether the measurement is performed in plasma or in serum. We analysed epidemiological and clinical features of every medical report. Obesity has become one of the most profound public health concerns, closely linked to increased morbidity, mortality, and social, occupational, and psychological discrimination.

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The diagnosis of CP is still accomplished using the standard scoring based on nine criteria, all considered verapamil cr 240 mg to be of equal value. To assess the medium- to long-term histopathological changes after coblation (cold ablation) inferior turbinate (IT) reduction (CITR) surgery for refractory IT hypertrophy.

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In contrast, penicillin G plus gentamicin (1.5 or 0.75 microgram/ml) sterilized only 2 of 15 in vitro vegetations at 5 days. Experimental support is lacking, the chemistry underlying the use of the product is oversimplified and the concept that ectopic calcification erdon store phila is simply the result of supersaturation is biologically flawed.

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The clinical efficacy was estimated and the changes of T-lymphocyte subsets in peripheral blood as well as the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) were observed. This article reviews the major clinical trial data that is the clindamycin dental infection dosage basis for the current chemotherapy regimens used as first- and second-line treatments for advanced pancreatic adenocarcinoma. Neurofibromin (MW 320 kDa) is the protein responsible for the pathogenesis of neurofibromatosis type 1 (NF1), one of the most common genetic diseases worldwide.