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Dutagen (Dutasteride)
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Dutasteride

Dutagen, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type 1 and type 2 5-alpha-reductase isoenzymes approved for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) who have an enlarged prostate. It has been demonstrated to be effective as monotherapy, or in combination with the alpha-adrenergic antagonist (α-blocker), tamsulosin, in several randomized, double-blind, placebo controlled trials and their open-label extensions. Treatment with Dutagen is generally safe and well tolerated. Dutagen has become established in the management of men with lower urinary tract symptoms (LUTS) and reduces the risk of acute urinary retention and surgery related to BPH. Dutagen may also have a role as a chemopreventive agent in the future as emerging evidence demonstrates a reduced risk of prostate cancer with this agent.

Other names for this medication:
Dutasteride, Deetor, Duodart, Duprost, Dutagen, Dutas, Dutasterida, Dute, Veltride,

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Perspective: a dynamics-based classification of ventricular arrhythmias. Data from patient interviews were analysed to corroborate provider practice self-reports. Nude rats bearing SKLMS-1 tumors in their hind limbs underwent ILP with escalating doses of AdLacZ or AdFLAGp53 (study 1), or with Ad.CMV.GFP.RGD or Ad.hTC.GFP/E1a.RGD (study 2) following in vitro confirmation of therapeutic potential in STS cell lines and strains. Male managers more often reported conflicts with superiors, lack of support, and personal life-work interference. Immunological responses of hamsters in the acquired immune state to Mycoplasma pneumoniae infection.

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Ethanol and other drugs of abuse modulate cAMP-PKA signaling within the mesolimbic reward pathway. Analysis demonstrated high biocompatibility of the binding polymers and permitted the identification of several different cellular morphologies, showing that specific polymer interactions may provoke changes in cell shape. A higher proportion of Middle Eastern patients were genotype 4 compared to equivalent studies from Western Europe, USA and Japan.

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Evaluation of insulin resistance in a cohort of HIV-infected youth. She was then commenced on mycophenolate mofetil and together with regular plasmapheresis, cyclosporine and prednisolone, her symptoms have finally improved and brought under control. Recruiting and retaining blood donors is of utmost importance, especially since there is no alternative for human blood.

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The skin edge at the most superior apex of the wound is sutured to the linea alba, thereby inverting the skin and fixing it to the sheath. PSMA/iNOS produced cytotoxicity in both androgen dependant and independent cell lines. Levels and distributions of polychlorinated biphenyls in sewage sludge of urban wastewater treatment plants.

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Compared to national and international references, our population is more similar to the American reference population than the national population, with a healthier growth pattern that could be related to the nature of the less urbanized community, the policies limiting the fast food chains inside the housing city and the presumed higher physical activity of children in our population. In this study, we considered the association between the serotonin receptor 1A (HTR1A) and 2C (HTR2C) SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI), in a sample of suicide patients and healthy volunteers. In Experiment 2, we used change-detection and backward-masking tasks to obtain separate within-subject estimates of K and of rate of encoding, respectively. We present the case of a patient who came to the emergency room with bilateral internuclear ophthalmoplegia who was later diagnosed as TMS. The ERR for cancer induction in breasts, lungs, and thyroid was estimated using both linear and nonlinear models.

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The CAG repeat region encodes a polyglutamine tract that, when expanded to above 40 in number, results in KD, a neurodegenerative disease primarily targeting lower motor neurones. Therefore, it is important to work from a model in design or implementation. Presentation of a missed injury of a metatarsophalangeal joint dislocation in the lesser toes. Rubella in pregnancy as an aetiological factor in congenital malformation, stillbirth, miscarriage and abortion. It must be distinguished between a specific protein replacement therapy in cases of acute protein losses and a calorically adequate parenteral nutrition in chronic deficiency states and calorie deficits.

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Alternative radiographic procedures should be considered when evaluating patients following TDR. Copper speciation survey from UK marinas, harbours and estuaries. To assessment acute and chronic toxicity and local irritative effect of antibacterial peptide complex (ABC) substance extracted from interferon preparations. With these new methods we can expect to lower the rate of false-positive and false-negative cytology tests as experienced with the traditional Papanicolaou-method, of not eliminate them completely, gaining thereby great advantages for patients and for cost-efficiency.

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Although these IRGs are highly induced following drug exposure early in infection in the mouse hollow fibre and aerosol models, correlating with potent bactericidal activity of the drug, their expression levels are markedly diminished during late-stage infection in these two models, coinciding with the greatly reduced bactericidal activity of isoniazid against these organisms. In normal nasal mucosa, UCN and CRF receptors were restricted to the vascular endothelium of submucosal cavernous sinusoids where faint staining was found.

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Defective assembly and trafficking of mutant HERG channels with C-terminal truncations in long QT syndrome. In mammalian cells, Mip130/LIN-9 specifically associates with the p107/p130-E2F4 repressor complex in G0/G1 and with B-Myb in S-phase. We find that Dicer deletion results in a substantial reduction of iNKT cells in thymus and their disappearance from the periphery, unlike mainstream T cells. The kinesin involved is kinesin-1, and Smad2 interacts with the kinesin-1 light chain subunit. Genetic tools for studying adaptation and the evolution of behavior.

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Intraductal papillary-mucinous neoplasms of the pancreas seem to comprise various types, whose relationship to ductal adenocarcinoma and mucinous noncystic carcinoma is unclear. Foam sclerotherapy is a highly effective and safe method for the treatment of primary and RV veins. Minimally invasive therapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia. A radioimmunoassay for the human isozyme carbonic anhydrase III (CAIII) has been developed.

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This study provides quantitative estimates of the dose-time and dose-volume relationships for human skin and normal mucosa in the head and neck region based on an analysis of data from 918 patients entered into a randomized-controlled trial of altered dose fractionation in radiotherapy. Automatic semantic activation is no myth: semantic context effects on the N400 in the letter-search task in the absence of response time effects. ADP initiates platelet aggregation by simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12.

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Morphologic changes in the photoreceptor layers correlated with duration of enrofloxacin administration, with generalized degenerative changes evident after 3 doses. Cohort study of patients undergoing surgery between July 2012 and September 2013, utilizing prospectively collected data from the Michigan Surgical Quality Collaborative. The aim was to evaluate heart muscle function in asymptomatic adult survivors of ALL treated in early childhood in relation to the combined effects of AC and other potential cardiotoxic factors. Although the diagnosis of GID is generally established by psychiatrists, the diagnostic team always includes an endocrinologist, who is responsible for hormonal therapy. Better knowledge of these risks has favourably influenced the legislation banning smoking in enclosed public places in France and in other countries.

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Comparative analysis of methods for detection of anti-laminin 5 autoantibodies in patients with anti-epiligrin cicatricial pemphigoid. In the current study, the explanation for the lack of induction by these altered ribosomes was investigated. Chelation therapy was instituted, with reversal of the clinical and biochemical effects of zinc poisoning. Stage 3: Characterised by a destructive injury of the trapezo-metacarpal joint. The sensitivity to cisplatin and doxorubicin in these transfectants was determined by trypan blue exclusion.

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To investigate enhancement of immune response to hepatitis B vaccine in immunosuppressed mice by CpG oligodeoxynucleotide (ODN). Multilocus phylogenetic analyses of Hispaniolan and Bahamian trunk anoles (distichus species group). Using amino and carboxyl group containing silanes, silicone nanofilament templates were chemically modified to mimic anionic and cationic exchange resins.

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Investigation of neuroprotective effects of cyclooxygenase inhibitors in the 6-hydroxydopamine induced rat Parkinson model. In lower risk patients, bilateral IF-NSP technique does not result in significantly higher PSM rates. Based on calretinin expression in axons, the core/shell compartments of the dorsal claustrum start to be clearly seen at embryonic day 18.5 and may be related to the development of the thalamoclaustral input. Here we report how the corresponding class of compounds was derived from a tri-peptide library and the first optimization round to improve both in vitro activity and physicochemical properties.

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In a previous publication, we showed that treatment of acutely sick, frail elderly patients in a Geriatric Evaluation and Management Unit (GEMU) reduced mortality considerably when compared with the general Medical Wards (MW). Metastatic medullary thyroid cancer (MTC) is an incurable disease once metastasis becomes unresectable. Among these tests, aniline blue and CMA3, and semen parameters, sperm morphology, and sperm motility showed a significant correlation with fertilization rate.

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Patients with pacemakers, atrial fibrillation or beta-blocker therapy at the time of biopsy were excluded. Brachial plexus injuries are usually a result of road traffic accidents and a cause of severe disability that typically affects young adult males. Based on data from a longitudinal study, this report considers two distinct aspects of semi-continuous alcohol use data. We found that, after the infection, Salmonella persisted for as many as 7 d in many extraintestinal tissues, while it was present in the feces of infected animals for all 14 d of the experiment. Improved steady-state diffusion approximation with an anisotropic point source and the delta-Eddington phase function.

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Renal biopsies, as well as glomerular isolates, urine samples, and blood samples were compared in BAY 41-2272- and placebo-treated groups during anti-Thy1 nephritis. We examined the hypothesis that recombinant human soluble thrombomodulin (rhTM) is effective in the treatment of patients with septic shock with sepsis-induced DIC after laparotomy for intestinal perforation.

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The goal of this study was to compare delay-sensitive and delay-insensitive deconvolution PCT in terms of delineation of the ischemic core and penumbra. Although periodic activity appears to be a hallmark of cortical neurons, little is known about the dynamics of these activity patterns as signals progress within local cortical circuits. The occurrence of myoclonic manifestations of the face or neck associated with the absences did not influence the benign course of their disease. Sequence analysis of a soil-borne wheat mosaic virus isolate from Italy shows that it is the same virus as European wheat mosaic virus and Soil-borne rye mosaic virus.

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Two studies were performed to investigate whether physical exertion has a significant effect on bodily signals stemming from emotional episodes with subjects having various degrees of affect intensity: 1) a statistical analysis using the Wilcoxon Test, and 2) a cluster analysis using the Davies-Bouldin Index. The impact of fragmentation of hospitalist care on length of stay. These cytotoxic lymphocytes can lyse erythroid progenitors in vitro, and the physiologic lower levels of HLA class I antigens on the erythroid lineage may contribute to this form of autoimmunity. In this study, we evaluated the effect of MAGE-D1 plasmid transfection on the growth, migration and invasion of breast cancer cells.

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Combining bioinformatic analyses, immunoblotting and immunohistochemistry of patient samples, we demonstrate that Plexin-B2 is consistently upregulated in all types of human gliomas and that its expression levels correlate with glioma grade and poor survival. Field testing of hearing protectors bridges the gap between the laboratory estimates of attenuation and the real-world attenuation achieved by workers as they normally wear the protectors. We, therefore, investigated the effect of the pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) on the expression and activity of BCRP and P-gp in the human hCMEC/D3 cell line. Reexamination of the intraurethral pressure determination using CO2 perfusion: its monitoring mechanism, standardization, and employment for the determination of the urethral constitutive property.

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