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Genoxal (Cyclophosphamide)
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Cyclophosphamide

Genoxal is used in the treatment of chronic lymphocytic leukaemia, lymphomas, soft tissue and osteogenic sarcoma, and solid tumours. It is given orally or intravenously. Genoxal is inactive until metabolized by the liver. Before you begin treatment with Genoxal, you and your doctor should talk about the benefits of this medicine as well as the risks of using it. This medicine is available only with your doctor's prescription.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Genoxal is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Genoxal is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Genoxal is also used for some kinds of kidney disease.

Genoxal interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by Genoxal, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with Genoxal, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule
  • Powder for Solution
  • Tablet

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Isolation and characterization of soybean-associated bacteria and their potential for plant growth promotion. Furthermore we propose that this link will provide a framework that will allow scientists to address seemingly intractable problems such as motion sickness or subluxation. At our hospital, available inventory and PLT selection practices resulted in the majority of group O patients receiving cellular-incompatible PLT transfusions.

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Differentiation of pseudodyskinesis of inferior left ventricular wall from inferior myocardial infarction by assessment of regional myocardial strain using two-dimensional speckle tracking echocardiography. Mutagenic screening of some commonly used medicinal plants in Nigeria.

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Response to measles, mumps, and rubella revaccination among HIV-positive and HIV-negative children and adolescents with hemophilia. Cyclooxygenase-2 in transitional cell carcinoma--a legitimate target? and Leishmania (Viannia) guyanensis (Kinetoplastida: Trypanosomatidae) in the neotropical sand fly Lutzomyia longipalpis (Diptera: Psychodidae). In an effort to both clearly define the molecular basis for the HD trait and develop tools to improve the introgression of this difficult-to-screen trait, this study focuses on mapping the QTLs linked to this trait.

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It was hypothesized that high self-efficacy would weaken stressor-strain relations when accompanied by frequent use of active coping and infrequent use of avoidance coping. Sixty patients were studied, 33 with documented episodes of paroxysmal atrial fibrillation (PAF) and 27 control patients. Machine learning based methods have been used in this area with great success. This recommendation is based on the observation of studies where it has been shown in binge drinking and chronic ethanol feeding animal models that betaine prevents liver injury resulting from high blood alcohol levels. Reporting in studies of protein biomarkers of prognosis in colorectal cancer in relation to the REMARK guidelines.

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Although some individuals in this area have been affected by drinking DPAA-containing water, toxicological findings on DPAA are limited. Mechanisms of adiponectin regulation and use as a pharmacological target. Original research publications in the literature about the contribution of particle morphology to the aerosol performance of pharmaceutical powders have been selected, including both the lactose carriers and the drugs.

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A number of echocardiographic tools have been developed during the past three years for such purpose, include M mode measurement of septal-to-posterior wall delay, tissue Doppler imaging for septal-to-lateral wall delay, the measurement of standard deviation of peak contraction time over 12 left ventricular segments, delayed longitudinal contraction, and potentially three dimensional echocardiography. New drugs are urgently needed to reduce the potential impact of the emergence of multidrug-resistant strains of the causative agent Mycobacterium tuberculosis (Mtb). However, all strains are gradually moving towards definitive mutations.

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Treatment is best viewed as comprised of two phases, weight restoration and normalization of eating behavior followed by relapse prevention. The chromatographic results are given as the retention, separation and resolution factors, together with the enantioselective free energy difference corresponding to the separation of the enantiomers. Moreover, the evidence on the relationship between pesticide exposure, dysregulation of the immune system and predisposition to different types of psychiatric disorders, cancers, allergies, autoimmune and infectious diseases are criticized. An analytical review of the Chinese literature on Qigong therapy for diabetes mellitus.

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Sirolimus-eluting stent implantation is superior in reducing angiographic restenosis and improving 9-month clinical outcomes in patients with DM and coronary artery disease compared with PES implantation. However, the pathways of secretion and O(2) generation are stimulus-specific and can be dissected to establish cause and effect relationships by means of: a) kinetic analysis, b) variations in the stimulus, and c) use of impermeant reagents to block discrete responses. Transient protein-protein interactions have key regulatory functions in many of the cellular processes that are implicated in cancerous growth, particularly the cell cycle. There was a quantitative increase in epithelial mucus production at a time before stones were formed and this increase persisted till stones were formed. These data provide the first evidence of the short-term safety of erythropoietin at high doses combined to quinine.

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This initial report from the multi-centered CardioSEAL VSD registry demonstrates the safety of the device to close high-risk VSDs. The role of the intrinsic apoptosis pathway in platelet life and death. Ro 320432, PKC inhibitor also reduced the effects of Der f 2-induced PLD activation suggesting that PKC-alpha acts as upstream activator of PLD in Der f 2-treated T cells.

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One of the goals of the national health reform is to promote a healthy lifestyle in all the population. Furthermore, interactions between new-created yellow alleles were observed. We report experimental observations of shell buckling instabilities in free-standing, vertically aligned GaN nanotubes subjected to uniaxial compression. The changes of a skin and hypodermic are studied at the prolonged introduction (till 3 months) original acupuncture needles under a skin of an auricle and neck at rats by the technique Muhina M.M. To this end, taking into account the central importance of fusion in a wide range of cellular processes, we may anticipate its control to open novel possibilities also for therapeutic intervention.

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These results suggest that the antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems, such as the noradrenergic and serotonergic systems, which project from supraspinal sites to the spinal dorsal horn. Two hundred eighty-six patients undergoing coronary artery bypass graft surgery. This peptide, which self-assembled into coiled coil dimers and tetramers, was then used to produce triblock peptide-PEG-peptide bioconjugates that self-assembled into viscoelastic hydrogel biomaterials. Our simulation shows that in such confinement system, the microphase structure of diblock copolymer strongly depends on the pitch, shape, size, and rotation of the pillar as well as the surface field of confinement.

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Function of glial cell network as a modulator of neural cell death during retinal degeneration Photocontrolled self-assembly and disassembly of block ionomer complex vesicles: a facile approach toward supramolecular polymer nanocontainers. Reversible posterior leukoencephalopathy in systemic lupus erythematosus with thrombotic thrombocytopenic purpura. As these devices proliferate, many patients will be in areas remote to their implant center. Patients with difficulty ingesting enough nutrients and fluids for weight maintenance and fluid balance may benefit from nocturnal enteral nutrition and hydration.

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Two organotin catalysts, namely, dibutyltin dilaurate (DBTDL) and dibutyltin diacetate (DBTDA), commonly used in the synthesis of polyurethanes, have been investigated combining vibrational spectroscopic measurements with molecular modeling. Assessing the capacity to make everyday decisions about functional problems: where does the field go from here? We determined the absolute configuration at the SO center by combining X-ray and NMR measurements with quantum chemical calculations.

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In the present study, we examined the direct effects of PCB on rat Leydig cells in vitro. Although stochastic actor based models (e.g., as implemented in the SIENA software program) are growing in popularity as a technique for estimating longitudinal network data, a relatively understudied issue is the consequence of missing network data for longitudinal analysis. After 5 courses were administered, Abdominal CT revealed that the size of the main tumor at S8 had not changed, and that portal vein tumor thrombus had disappeared.

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Children with disabilities are particularly vulnerable to participation restrictions resulting from the interactions between children and their physical and social environments. Particulate steroids have been known to play a role in embolism. PTC and stenting procedures are associated with significant risks including life-threatening haemorrhage, sepsis, renal failure and high mortality rates. Furthermore, those with increased voice calls and SMS exposure over the 1-year period showed changes in response time in a simple reaction and a working memory task.

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Likewise, we lack knowledge on female fecundity-consequences of matings and the degree of male mating harassment in natural settings. They suggest both a sex-specificity and a relatively short gestational time-window for gestational effects on vulnerability to schizophrenia. General information, lifestyle factors, serum and urinary concentrations of Mg and cardiometabolic factors were determined.

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Pharmacogenomic Biomarkers for the Prediction of Statin Efficacy and Safety Geocoding capacity of birth defects surveillance programs: results from the National Birth Defects Prevention Network Geocoding Survey.

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Circulating E-selectin and tumor necrosis factor-alpha in extraarticular involvement and joint disease activity in rheumatoid arthritis. To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acetylgalactosaminyltransferase 1)-null mice. A retrospective clinical study was undertaken over a 5-year period for consecutive patients operated on for anal stenosis. On haemodialysis, my life was not my own - handing control to nursing staff for 4 hours, 3 days a week, surrounded by noisy machines and unhappy patients, returning home after 11 hours, too exhausted to eat and falling into bed. To explore the association between genetic polymorphisms of XRCC1, XPD, XRCC3 and CCND1 and latency of occupational chronic benzene poisoning.

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The relationship was analyzed for the serum VEGF-C level, VEGF-C and LYVE-1 expression of primary cancer and mediastinal lymph nodes, mediastinal lymph nodes metastasis and the 3-year survival rate of the patients. Existing clinical and experimental evidence generally supports a pathogenic role of autoantibodies for blister formation. All the tested TLRs including TLR1, TLR2, TLR4, and TLR5 and myeloid differentiation factor-2 (MD-2) were expressed on SGT and HSG cells.

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The problem of complications of percutaneous coronary interventions. Gene expression of lung squamous cell carcinoma reflects mode of lymph node involvement.

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We observed that narcoleptic canines, like narcoleptic humans, also exhibit jerky, unilateral or bilateral slow leg movements during sleep. During chronic pain, the activity in the lateral reticular formation of the caudal ventrolateral medulla changes, so that the action of the caudal ventrolateral medulla upon SP-responsive spinal neurons shifts from inhibitory to excitatory. Experiences with the treatment of chronic hepatitis C and prognostic factors for its efficacy in clinical practice

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Abdominal aortic aneurysms (AAAs) share common risk factors with atherosclerosis, except for diabetes which appears protective. The regulation of the shift in pyruvate metabolism was investigated by monitoring the dynamic behavior of L. A similar result was obtained when cells were incubated with betulinic acid, an inhibitor of the diacylglycerol acyltransferase.

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Moreover, MDR3 mutations predispose to cholestasis of pregnancy and drug-induced cholestasis. In conjunction with basic research studies, fMRI has been increasingly applied in clinical disorders, making it a central research tool in human psychopathology, psychopharmacology, and genetics.

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A novel monoclonal antibody SMab-2 recognizes endogenous IDH2-R172S of chondrosarcoma. Resection of the body and tail of the pancreas (distal pancreatectomy) is associated with high postoperative morbidity, most of which is due to leakage from the pancreatic transection surface.

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Hypothermia conserves ATP in hypoxia-ischemia, possibly by preserving HPRT activity. Authors also provided dynamic measurements of the foot, which produced several significant findings that we discuss. Furthermore, IgMs are potent activators of the complement system. To minimize the mutual interference of the two modalities, glass microelectrodes were used rather than metal and a noise removal algorithm was implemented for the electrophysiology data. Using these animal models we could recently show that the immune system is involved in the pathogenesis of hereditary neuropathies.

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Here, we find that autophagy intersects with human immunodeficiency virus (HIV) biogenesis, mirroring the above dichotomy. Regarded as an isolated population, the Minz (Hei-Yi Zhuang) in Napo County (in the China-Vietnam borderland) has been the subject of numerous recent studies. Loss of PTEN causes unregulated activation of downstream components of phosphatidylinositol 3-kinase (PI3K) signaling, including PDK1, and disrupts normal nervous system development and homeostasis.

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Posttraumatic stress disorder and health-related quality of life in pension-seeking Canadian World War II and Korean War veterans. Survival time was counted from the date of the histopathological diagnosis and the date of death due to breast cancer was considered the adverse event. Atmospheric pollution by PAHs, PCDD/Fs and PCBs simultaneously collected at a regional background site in central Italy and at an urban site in Rome. Therefore, we had covalently coupled CCK to a 10 kDa polyethylene glycol and showed that this conjugate, PEG-CCK(9), produced a significantly longer anorectic effect than unmodified CCK(9). The activin type II receptors are of particular interest, since they bind a large number of diverse ligands.

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The effects of the PDMP on oxycodone-caused mortality in Florida were evaluated. We explored the oncological effectiveness of inferior vena caval resection, as determined by margin status, cancer recurrence and survival. A novel bacterium designated strain B-16 was isolated from the compost leachate of the municipal solid waste (MSW) in a laboratory reactor. Endoscopic ultrasound identified perforators in seven cases of DV. An open-label study of an herbal topical medication (QoolSkin) for patients with chronic plaque psoriasis.

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New findings suggest that these substances can help in prevention and treatment of AD. The protein-protein interactions involve regions similar to those observed in the oligomerisation of the native crystals and those employed to set up the functional tetramer. Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies. Multichannel recording and stimulation of neuronal cultures grown on microstamped poly-D-lysine. Furthermore, confocal microscopy of newborn mouse thyroid glands revealed colocalization of calcitonin and E-cadherin in the C cells.

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Only in the cases of phthalimides, bearing mixed ether-thioether N-substituents, do these excited-state cyclization reactions proceed with lower degrees of regioselectivity. OBJECTIVE: The dynamic response and load sharing amongst passive elements of an L2-L3 motion segment during axial compressive cyclic loading was investigated. JunD overexpression increased the transcriptional activity of an AP-1 luciferase reporter construct, and this activity was reduced by co-transfection of menin. The BAC library should expedite complete genome sequencing of C.

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After piloting a larger pool of items, 13 statements were used to construct the Knowledge Test BEC. Further investigation of this was refused by the patient but then years later a repeat intravenous pyelogram showed persistence of the initial intracalyceal filling defect and ureteral obstruction in the contralateral kidney along with multiple intracalyceal radiolucent filling defects.

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Evaluating the impact of X-ray spectral shape on image quality in flat-panel CT breast imaging. Aqueous suspensions of length selected single-walled carbon nanotubes were studied by atomic force microscopy (AFM) in order to probe the influence of sonication on nanotube scission. We determined the significance of CTS in transthyretin Val30Met-associated familial amyloid polyneuropathy (FAP ATTR Val30Met) by comparing the electrophysiological indices of the median and ulnar nerves in 58 patients. ORGANISATION: The CRASH trial will determine reliably the effects on death and disability of a short corticosteroid infusion following significant head injury.

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Buprenorphine seems to be at least as effective as methadone for opioid withdrawal in young addicts. Upon reduction, singly bonded 1,2,4,15-C60 dimers with an oxazoline or imidazoline heterocycle dissociate into monoanionic 1,2,4-C60 intermediates, which surprisingly leads to the formation of 1,2,3,16-C60 rather than 1,2,4,15-C60 adducts of the original configuration by further benzylation, even though the analogue of dibenzylated C60 oxazoline with a 1,2,4,15-configuration is stable and has been obtained.

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Animals were euthanized 7 to 10 days after inoculation and examined for signs of abscess formation. The pain scores at 6 and 12 hours after surgery in the preemptive group were significantly lower than in the control group. The interface interactions between surfactants oleic acid and oleylamine and magnetic nanoparticles are studied via molecular mechanics and dynamics. The results are also valuable since soluble cellulose derivatives are generally used as substrates during enzyme characterization and in endoglucanase activity assays. Even though mortality remains high, their recognition is important since survivors may have an excellent long-term prognosis.

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Although the C-terminal region is believed to be responsible for apoptosis induction, the functions of more membrane-proximal domains, including the domain that couples to neutral sphingomyelinase activation, are not yet fully elucidated. The use of temporal lobectomy for the treatment of intractable complex partial seizures of temporal lobe origin has a long and successful history. The paper discusses the negative attitudes of some nursing assistants in Slovenia towards higher ip 253 zantac vs prilosec nursing education and academic (theoretical and research based) knowledge.

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In contrast, for South Asian patients, most quality measures in either study did not differ by physician ethnicity. Further complicating the assessment is the altered anatomy and physiology that result from pantoprazole injection 40 mg the enlarged uterus displacing and compressing normal anatomical structures. Previous cladistic analyses have indicated that these anatomical types represent separate evolutionary origins of the C(4) pathway, and the differences in developmental pathways observed here reflect these independent origins from C(3) ancestors.

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Osteopontin is a glycoprotein secreted for the initiation of the Th1 immune reaction, as well as for extracellular matrix formation and calcium deposition in the bone and kidney. The interplay between hydrogen ions, bicarbonate ions and osmolality in the anterior duodenum modulating gastric function in the conscious calf. Plasma levels of adiponectin did not change after the increase in dietary intake of ALA in the flaxseed contramal fiale image oil supplementation group, compared to the control group. Production, stability, and antioxidative and antimicrobial activities of two L-ascorbate analogues from phycomyces blakesleeanus: D-erythroascorbate and D-erythroascorbate glucoside.

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Adenosine amine congener mitigates noise-induced cochlear injury. A comparison of measured omezol 20 capsules for nespresso BPA environmental concentrations with chronic values suggests that no significant margin of safety exists for the protection of aquatic communities against the toxicity of BPA. The presence of salt water is essential in plasticizing PECs to allow them to be reformed and fused. Utility of the Portex introducer, ivory type, as a tube exchanger.

cyclophosphamide mode of action ppt to pdf 2010-11-09

This in vivo functional comparison between TRAF6 and MyD88/TRIF deletion in IECs shows that the colitis-protecting effects of epithelial TRAF6 signalling are not triggered by TLRs. Such normalization assumes constant HKG gene expression under all circumstances. The smallest safe margin of distal clearance for lower rectal cancer is very important for the operation. Gas exchange and hemodynamic changes thuoc zycel 100 mg resulting from the rehabilitative therapy of ischemic heart disease The ALT/AST ratio, FIB-4 and NAFLD fibrosis scores can reliably exclude advanced fibrosis in a high proportion of patients with NAFLD, allowing liver biopsy to be used in a more directed manner.

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Hoechst staining, cell proliferation and TUNEL assays, real-time quantitative PCR, Western blotting, chromatin zonalon dosage of amoxicillin immunoprecipitation and RNA interference were employed in investigating the role of induction of p14ARF by E2F1 in 8-Cl-Ado-induced apoptosis in human lung cancer H1299 cells. Detailed study of the anatomy of the ISJ has been surprisingly neglected and continues to be controversial. Therefore, maternal x-cxcr4b is specifically downregulated within PGCs at pre-migratory stages while it is expressed in other tissues. Two patients with metastatic carcinoma (one cervical and one testicular) in whom echocardiography was instrumental in diagnosing a right ventricular cavity mass are presented.

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It was found that leptin inhibited expression of all markers of cytoplasmic apoptosis (bax, ASK-1 and p53), stimulated expression of anti-apoptotic peptide bcl-2, but did not affect nuclear DNA fragmentation (TdT). In order to determine how much of an impact endometriosis-associated dyspareunia has on the lives metronidazole 2g single dose pregnant and relationships of women a qualitative study using semi-structured interviews, supplemented with quantitative data on the extent of dyspareunia, was conducted in a dedicated endometriosis clinic in the West Midlands, UK with 30 women aged from 19 to 44 years.

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EphA8-promoted adhesion was efficiently inhibited by wortmannin, a phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor. Results from experiments using transgenic and mutant mice, as well as in-vitro techniques, have identified genes and signaling pathways that are required to either specify unique auditory cell types, such as hair cells or supporting cells, or to generate the highly ordered cellular pattern that is characteristic for the organ of Corti. Monochorionic dizygous twinning is rare, but appears to be more common after assisted reproduction. To compare the effectiveness ofradial extracorporeal shock wave therapy (rSWET) and ultrasound therapy (US) in the treatment of chronic plantar fasciitis. Polypyrrole (Ppy) was selected as co-amoxiclav augmentin drug study scribd books a matrix for preparation of MIP.