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Topimax (Topiramate)

Topimax is used alone or with other medications to prevent and control seizures (epilepsy). This medication is also used to prevent migraine headaches and decrease how often you get them. Topimax will not treat a migraine headache once it occurs. If you get a migraine headache, treat it as directed by your doctor (such as by taking pain medication, lying down in a dark room). Topimax is known as an anticonvulsant or antiepileptic drug.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Topimax is used alone or with other medications to treat certain types of seizures including primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; seizure that involves the entire body) and partial onset seizures (seizures that involve only one part of the brain). Topimax is also used with other medications to control seizures in people who have Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Topimax is also used to prevent migraine headaches but not to relieve the pain of migraine headaches when they occur. Topimax is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain.

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A cis-spreading nucleoprotein filament is responsible for the gene silencing activity found in the promoter relay mechanism. Here we report, for the first time, a comprehensive qualitative model showing the importance of acid-base complex formation between oleic acid and oleylamine as well as the presence of free protons in the engineering of nanoparticles of specific shapes and sizes. After a single-incision laparoscopic surgery port was introduced into the anal canal, a pneumorectum was established with a laparoscopic device followed by transanal excision with conventional laparoscopic instruments, including graspers, electrocautery, and needle drivers. A corrective osteotomy for post-traumatic malrotation and shortening of the femur.

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This investigation showed that the porous PVA/Gel/V-n-HA/PA6 scaffold is a potential matrix for treatment of osteochondral defects, and the method of using chondrogenically and osteogenically differentiated BMSCs as seed cells on each layer might be a promising strategy in repair of articular osteochondral defect due to enhanced chondrogenesis and osteogenesis. Experimental results from various animal models and preliminary clinical data have indicated the capacity of bone marrow-derived stem cells to home into infarcted heart tissue and promote cardiac repair. Therefore, D2-40, as an indicator for tumor lymphangiogenesis, may serve as a prognostic marker in gastric carcinoma.

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On the other hand, a larger portion of the nascent peptides of NADPH-cytochrome c reductase was detected in fraction S2 from free ribosomes than in other fractions. Urinary proteomics identifies CAD with high confidence and might also be useful for monitoring the effects of therapeutic interventions. Of the 4, levetiracetam appears to be easiest to use (ie, no need for dose adjustment in organ dysfunction, no need for laboratory monitoring) and best tolerated, and has not been associated with the unique toxicities seen with oxcarbazepine, topiramate, and zonisamide. Capillary permeability, rate of transcapillary exchange of chloride in the guinea pig as determined with radiochloride.

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Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats. Conversely, lowering ethylene biosynthesis reduced the number of somatic embryos in the high capacity cell line. We describe the case of a patient with a reported pseudocholinesterase deficiency requiring emergent prehospital airway management.

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These usually involve placement of permanent restorations, occlusal adjustments or periodontal flap surgery. After reviewing the main pathological features encountered, we describe the indications for the two bypass techniques used. When class labels of training data are available, Fisher discriminant analysis (FDA) has been widely used. Denaturing gradient gel electrophoresis analysis of bacterial communities associated with failed endodontic treatment. Each concept was given a unique identifier and mapped to Logical Observation Identifiers, Names, and Codes (LOINC).

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Our results indicate that this middle Pleistocene hominid fossil should be referred to as Homo erectus. Samples were stored dry in a light-proof container prior to testing. Tissue Doppler imaging as a long-term prognostic index in left ventricular systolic dysfunction.

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we explored whether cellular fusion and heterokaryon formation between human and rodent cells in the cerebellum of mice occurs after intravenous injection of human bone marrow-derived mesenchymal stem cells (MSCs). We speculate that CcLim15 and CcTopII work in cohesion between homologous chromatins initially and then, in the process of the zygotene events, CcUbc9 works with factors including CcLim15 and CcTopII as an inhibitor of ubiquitin-mediated degradation and as a metabolic switch in the meiotic prophase cell cycle. During his relapses, he experienced headache, and attention and language disturbance, but no visual symptoms. To describe a canthopexy technique without canthotomy that avoids release of the lateral canthal tendon for treatment of moderate lower eyelid laxity. The aim of the study was validation of this Bleeding Risk Score (BRS) tool among a subgroup of patients based on body mass index.

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Genotypic and phylogenetic analysis of the G gene of respiratory syncytial virus isolates in Okinawa, Japan, 2008. The literature on analysis of proteomics and metabolomics data is as yet sparse, so the main focus of this paper will be on methods devised for analysis of gene expression data that generalize to proteomics and metabolomics, with some specific comments near the end on analysis of metabolomics data by mass spectrometry and NMR spectroscopy. The present authors examined the effects of listening to music on psychophysiological parameters (blood pressure, heart rate, and respiratory rate) during preoperative and postoperative days and determined whether listening to music could lower pain intensity and opioid dosage during postoperative days in patients who underwent total knee replacements. We conclude that alternative splicing can regulate endogenous ANP/GC-A signaling. Statistical issues in a modeling approach to assessing bioequivalence or PK similarity with presence of sparsely sampled subjects.

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Results showed that early exposure to methylphenidate (5 mg/kg) increased the magnitude of morphine-induced CPP. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others.) It was found that these cell types reacted to the cements with different intensities, and that there were differences in evaluation by phase contrast microscopy and succinic dehydrogenase histochemistry. It is established that the ability to bind rivanol-SO2 by DNA in the women with a habitual abortion and a threat of pregnancy interruption is reduced in lymphocytes under a 72-hour cultivation as compared with a 24-hour one. We show that PKR physically interacts with either Jak1 or Tyk2 in unstimulated cells and that these interactions are increased in IFN-treated cells.

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Concerns about adequate anatomical renal vessel length and sufficient surgical exposure are the main obstacles to the use of the laparoscopic approach for right kidney live donors as well. For this reason, insulin resistance could be a physiological mechanism activated at the cellular level in response to conditions stimulating ROS production and leading to the prevention of oxidative stress, and extension of life. Metabonomics is concerned with the quantification of molecules in the metabolome and uses nuclear magnetic resonance (NMR) spectroscopy as one of the main technological platforms. Finding triploidy is possible by risk assessment (ultrasound and double test), and thereby women may have the opportunity for early termination of pregnancy. Experimental jet velocity and edge tone investigations on a foot model of an organ pipe.

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Current treatment for sepsis-induced cardiac dysfunction is based on appropriate treatment for the infectious focus (antibiotics and source control) and hemodynamic support (fluids, vasopressors, and inotropes). The relatedness of the detected norovirus strains was evaluated by phylogenetic analysis.

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Constraints on an annihilation signal from a core of constant dark matter density around the milky way center with H.E.S.S. Waist circumference and mesenteric fat in neonates: negative correlation. Pronounced hemodynamic changes have been found to be absent at the stage of anesthetic anesthesia and while turning the patient with to the prone position. As previous studies have shown that seminal plasma zinc is associated with a decrease of anti-oxidant defences, seminal plasma zinc could be a contributor to the effects of cigarette smoking on sperm parameters.

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Amlodipine, a dihydropyridine calcium antagonist, and valsartan, an angiotensin receptor blocker, are well-established antihypertensive agents with complementary mechanisms of action. The prospective investigation a was conduct in 218 patients and retrospective ones--in 253 patients. Mechanisms of synaptic depression triggered by metabotropic glutamate receptors. In 9 horses, the arrhythmia disappeared after retraction of the forceps and introducer sheath. Microstructural abnormalities in children with post-traumatic stress disorder: a diffusion tensor imaging study at 3.0T.

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Current trends, examples of regulations and practical approaches to occupational health services in the United Kingdom. Validating a tool to examine the capacity of health organizations to use research.

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On the other hand, long-term exercise modulates the expression levels of this gene. Binding of Ac-TZ14011 to CXCR4 on the cell membrane was observed by fluorescence microscope, and analysis of the binding data produced IC 50 values of several ligands comparable to those obtained in RI-based assays. Further advances in the etiopathogenesis and earlier diagnosis are only likely with the advent of a species specific feline thyroid-stimulating hormone assay.

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Meta-population structure, methodological issues associated with estimating survival, or processes shaping range boundaries could potentially explain the nature of elevational shifts in life-history traits evident in this data set. Although the magnitude of radiation doses in general radiography is low compared to computed tomography and fluoroscopy, the dose to the patient is more critical in pediatric examinations than in adults, because of the greater radiosensitivity of children. Group psychotherapy can be used to reduce the incidence of vomiting in advanced breast and lung cancer patients treated with chemotherapy.

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These were used to generate an H3-MGB RT-PCR assay that recognizes only H3 AIV. Pattern of carbon dioxide stimulated breathing in patients with chronic airway obstruction.

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Mice in groups that were immunized with VP6 spore vaccines plus CT or mLT showed significant reductions in virus shedding, whereas the groups of mice immunized with VP6 vegetative cell vaccines showed no difference in virus shedding compared with mice immunized with control spores or cells. Moreover, protein gene product 9.5-positive neuroepithelial bodies and airway ganglia were associated with dendritic cells.

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The presented SST could be an effective way to train intensive care specialists in severe sepsis management. Advances in ABO-incompatible HT in pediatric patients and ABO-incompatible abdominal transplantation in adult patients have led to clinical exploration of intentional ABO-incompatible HT in adults.

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Peripapillary staphyloma is occasionally included in this group but it does not represent an anomaly of the optic disc itself and is not discussed herein. When comparing back-calculated intake data of the DEHP metabolites with dietary DEHP intake from the day before significant correlations were observed for most of the metabolites.

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Chemotaxis is defined as the ability of living cells to determine the direction of locomotion through a concentration gradient of attractant and repellent substances. The levels of the peptide were found to be higher in the uninflamed human than in the rabbit aqueous humor which may be the result of species differences and/or age-related circumstances.

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Nerve injury marker ATF3 was markedly increased in ipsilateral trigeminal ganglion neurons at 8 days after pIONL. A method for determining blood flow, oxygen uptake and carbon dioxide release in individual organs is presented.

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Group IV rats were given enteral nutrition supplemented with fiber. They may present as unique signs of multi-system disease affecting the kidneys (such as vasculitis), or as common oral pathologies found at an increased prevalence in patients with end-stage renal disease. Nucleotide flipping by restriction enzymes analyzed by 2-aminopurine steady-state fluorescence. This improvement in performance typically manifests during the second year of thoracic surgery training. Meals did not have any effect except a slight decline of transferrin.

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Of 5 candidates, a specific siRNA that effectively inhibited HBV gene expression and replication was determined. The M1 shows a Y5 pattern of cusp contact and a well-developed and deep anterior fovea bounded posteriorly by a continuous midtrigonid crest. Yeast genes fused to beta-galactosidase in Escherichia coli can be expressed normally in yeast.

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Methods of solid-phase extraction (SPE) and ultra-performance liquid chromatography/(electrospray ionization) tandem mass spectrometry (UPLC/(ESI)MS(2)) were developed in parallel for detection of four natural androgens and four commonly studied estrogens, three natural and one synthetic, in aqueous matrices. The comparison of 99mTc-RBC SPECT and DSC-MRI measurements in our study indicates that DSC-MRI can be a useful method to measure CBV as a percent of brain volume.

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Eligibility criteria included human epidermal growth factor receptor 2-negative MBC, prior therapy with anthracyclines and taxanes, at least one prior chemotherapy regimen for metastatic disease or early relapse after a taxane plus anthracycline adjuvant regimen, and adequate organ function and performance status. These cells were arranged into sheets or tubules and were located predominantly in the lung parenchyma. Serum PRL, TSH, T3 and T4 were estimated in the basal state and following iv bolus injection of 100 micrograms synthetic thyrotropin releasing hormone before and 7 days after cyproheptadine treatment in 5 healthy adult males.

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They are essential to the development of cardiac left-right (LR) asymmetry by means of their function at the embryonic organizer (node). Four patients were identified with late endophthalmitis associated with Baerveldt glaucoma implants. Three different DR conditions, imposed by manipulating levels of different types of yeast sources, were tested in females and males of two lacZ reporter gene lines. ESWL for difficult bile duct stones: a 15-year single centre experience. Initially, the cells attached to the pulmonary vessels were rounded.

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Cloning of the gene for the QA-binding protein revealed that it is the fatty acyl carrier protein, AcpPSE, of the fatty acid synthase of S. When the Na concentration gradient is not yet completely equilibrated, addition of Ca2 causes an apparent efflux of Na against this gradient. Northern blots and in situ hybridization analysis showed that P26h transcripts appear at 3 wk of age, within the first round of spermatogenesis in the golden hamster. Other drugs like nucleoside reverse transcriptase inhibitors can produce genotype-specific POLG pharmacogenetic disease.

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Molecular modelling study of the role of cholesterol in the stimulation of the oxytocin receptor. Regioselective palladium-catalyzed synthesis of beta-arylated primary allylamine equivalents by an efficient Pd-N coordination. We found that the expression pattern varied for specific genes expressed by keratinocytes as confluence was reached. High rejection and infection rates result in poor patient and graft survival. We propose that lowered ILS results in metabolic and physiological changes.

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Methods such as hierarchical agglomerative clustering, k-means clustering, the self-organizing map, and model-based methods have been used. Though existing microbial community profiling methods have attempted to rapidly classify the millions of reads output from modern sequencers, the combination of incomplete databases, similarity among otherwise divergent genomes, errors and biases in sequencing technologies, and the large volumes of sequencing data required for metagenome sequencing has led to unacceptably high false discovery rates (FDR). The multiple electrode consists of an 8 x 8 array of 30 x 30 microm2 carbon micro electrode.

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The differentially expressed genes (DEGs) were screened using limma package in Bioconductor and miRNAs targeted DEGs were predicted. It is not known how many dental aspirators are in use that vent their waste air directly into the surgery or if this aspirator is representative of others in existence. Abdominal muscle strength was investigated using the Biodex System 4 including flexion, extension and isometric measurements.

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No nosological, nor genetic classification has been followed in this article. Racial and socioeconomic disparities in bone density testing before and after hip fracture.

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Toward a new understanding of attention-deficit hyperactivity disorder: advances in research and treatment. One unsolved reconstructive problem is the collapsed scaphoid that requires an intercalated wedge graft with proximal pole avascular necrosis. The clinical criteria included stability of the implants and the prosthesis, resonance frequency analysis (RFA), and evaluation of swelling, pain, or discomfort. Independent of season, day, time, and location, participants reported less quarrelsome behaviours, more agreeable behaviours and better mood when exposed to high but not low levels of bright light.

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European and Developing Countries Clinical Trials Partnership (EDCTP): the path towards a true partnership. The Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) maintains a (60)Co teletherapy source primarily for the calibration of therapy dosemeters. Mastectomy is often recommended when mammography shows a breast cancer with extensive calcifications.

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Finally, after experimental balloon angioplasty in hyperinsulinemic nondiabetic islet-transplanted rats, a significant increase in neointimal hyperplasia was observed. Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis.

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These initial studies indicate that the developed PEG hydrogels are suitable for release of stable proteins in drug delivery and tissue engineering applications. In a cohort of 84 Cypriots with unexplained renal disease, four had mutation in CFHR5. Echocardiography showed clear direct continuity between a hypertrophied anterolateral papillary muscle and the anterior mitral leaflet, and the left ventricular (LV) outflow tract (LVOT) was narrowed by the presence of an accessory papillary muscle. Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.

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They also describe some of the major attempts at creating animal models of schizophrenia, including drug and nondrug methods. Antibody isotype responses to paramyosin, a vaccine candidate for schistosomiasis, and their correlations with resistance and fibrosis in patients infected with Schistosoma japonicum in Leyte, The Philippines. Hospital transmission of Mycobacterium tuberculosis (TB) is a problem in US facilities where adults are treated.

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Global and regional brain glucose metabolism decline after systemic chemotherapy. ASTMMETRIC LEAVES1 and 2 (AS1 and ranisen ranitidina 150 mg comprimidos de omega-3 AS2) are two of these genes, which are critical for both of these two processes. Accurate and precise estimation of arterial blood pressure is needed for the management of hypertension.

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In complementary murine transplantation studies, we found that cells of hematopoietic origin contributed to the early inflammatory and late marrow-repopulating stages of BMP4-induced heterotopic ossification but were not represented in the fibroproliferative, chondrogenic, or osteogenic stages of heterotopic ossification. Although anxiety and depression are highly correlated in CHF patients, depression alone predicts a significantly worse prognosis for these patients. To evaluate peripheral arterial occlusive disease in HIV-infected patients regarding clinical presentation and outcome of surgical intervention. Human immunodeficiency virus (HIV) infection, which is responsible for dasabuvir ombitasvir paritaprevir and ritonavir brand AIDS, is one of the most widespread in the world.

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Patients Ninety patients with possible/probable Alzheimer disease who were being treated with cholinesterase inhibitors at baseline. In our study, the intestinal histological subtype had a favorable prognostic value. In the presynapse, the interaction between Ca(v)2.1alpha(1) and CaMKII and the phosphorylation of CaMKII (at Thr286) and its substrate Synapsin I (at Ser603) were decreased in mutant mice compared to wild-type mice. New guidance has been released by the National Institute for Clinical Excellence on the diagnosis and management of epilepsies in adults, children and young people. Therefore, the parents and carers of children with PFAPA must weigh the risks and consequences of surgery (hospitalisation, a predictable period of time postoperatively away from school/nursery, the risks of surgery) against the alternative of a finite reviews of epcon communities period of recurrent episodes of disease at predictable intervals, potentially requiring time off school and the regular use of medication.

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The A2 protein spiroctan 50 mg blocked flow-dependent platelet adhesion to fibrin, delayed fibrin polymerization, and inhibited platelet-fibrin clot formation in vitro. PI 3-kinase and MEK kinase inhibitors differentially affect IgE-dependent and IgE-independent basophil mediator release.

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